This is a reasonable question but the answer is not a simple Yes or NO. Here is a video from the Tire Information Association that covers the use of simple "plug" type repair.
This video shows an example of "hidden damage" and here is what that "saw tooth" can turn into. 
My post in 2017 has pictures of three examples of tires with internal damage that were improperly "plugged".
Obviously if just doing an external plug is improper then squirting "oatmeal" into a tire in the hopes it will block the air leak is not a good option.
It may look like this.
or your wheel like this
Squirt in "sealant" can also "seal" your TPM sensor so you have to buy a new sensor. You also need to consider that the use of aftermarket "sealant" can void the tire warranty and even make it impossible to do a proper repair.
If you must use a plug, use it to get off the road and to the nearest service station where you can have the tire dismounted and completely inspected.
##RVT978
I haven't thanked you yet for providing this wonderful and valuable service. When I started shopping for an RV I would have been screwed many times over on "new" tires had I not found your blog first. Everyone has "new" tires....even ones full of cracks and checks. I was able to get past that just with your advice about how to read the date on the tires. Thanks again. I am an avid reader of every post and then some. Happy holidays. Think positive and test negative bro.
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